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Physics and Biology in Medicine Graduate Program

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Molecular Imaging Specialization

Goal

The goal of this track is to educate students in the basic concepts, the development and application of a range of quantitative technologies for studying biological systems. A particular emphasis is given on preclinical and clinical imaging using positron emission tomography (PET). Graduating students should be well prepared for the many career opportunities in quantitative assays of biological systems and imaging (both in academia and industry) or for careers in a clinical nuclear medicine environment. This includes research in the areas of:

  • Development, engineering and chemical synthesis of novel molecular imaging probes
  • Systems biology for the study of disease and physiologic processes
  • Biological assays based on new molecular markers
  • Design and development of new PET, x-ray CT, charged particle and multimodality imaging systems
  • Tomographic image reconstruction and multimodality image registration
  • Quantification in PET imaging
  • Development of miniature nuclear imaging systems (e.g. intra-operative applications)
  • Pharmacology and biochemistry of radiolabeled and fluorescently labeled compounds
  • Development of tracer kinetic models for new compounds
  • Parameter estimation in autoradiography and positron emission tomography
  • Imaging gene expression with PET, autoradiography and MRI
  • Pharmacology of brain and cardiac receptor systems
  • Study of metabolism, blood flow, transport and synthesis in the brain and heart

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